Rebirth of the God-level Xueba

After Arnold finished the phone call, he came back excitedly to announce the good news. He saw that Yang Rui had already drank a pint of beer with a table of pharmaceutical company representatives.

Arnold's eyes turned red in an instant, as if a man went out to buy a green onion and came back to find three used condoms in the kitchen, or a man rushed out to buy a condom and came back to find six broken ones in the bedroom of bitter gourd.

Arnold felt bitter like a snapped organic bitter gourd—my life, my struggle, and my goal were not to do this kind of thing!

"Arnold is here. Let's drink together." Yang Rui invited Arnold to the table as if nothing happened, and even called him by nickname.

Arnold sat down on the table coldly under the gazes of all his peers, and said, "Yang Rui, I thought it was true that you promised to give Zeneca the right of first refusal."

"Of course it is true. Before signing a contract with any company, I will tell Zeneca to give you a short time to quote." Yang Rui put down his beer glass and said.

This is what priority is all about. Arnold had nothing to say, and said disappointedly: "I thought you would give us a chance to talk about it first, in private."

"If it's because of affection, I don't want it anymore." Yang Rui knew what Arnold thought. The cooperation between the two parties has become inseparable to this day. Well refused.

"The conditions of Zeneca will definitely satisfy you." Arnold wanted to do additional questions too much, especially if he didn't answer the basic questions very well.

Yang Rui said: "I know that Zeneca will give excellent conditions, and it is enough to make up for the contribution of Huarui Laboratory, maybe it is enough to make up for many times that of Huarui Laboratory, but I have to be responsible for Huarui, including myself. The researchers inside are responsible, and we want the best conditions."

Yang Rui looked around and said, "Deferiprone is my first achievement in the field of pharmacology, and it is also the first achievement of Huarui Laboratory. I don't know whether it is ability or good luck, or just a flash of inspiration. , I have to fight for what I can, that's my job, right?"

"I admit that what you said is very reasonable. You want to cash in an insurance for Huarui so that it can continue to operate for many years. I can understand, but I want to say that Zeneca can be your insurance company. A good relationship with Zeneca can also ensure the long-term operation of Sinovel Labs.” Arnold has a lot to say, but he chose this statement because it is a condition that only Zeneca can propose.

No matter how big other companies are, they dare not make such a guarantee without the basis of cooperation with Yang Rui.

Yang Rui picked up the beer glass and took a sip, letting the wine swirl in his mouth, feeling the bitter taste.

"Yang Rui, the resources owned by Zeneca are world-class. What we can provide to you is more likely to be the world's number one. I can guarantee that even if, I mean, even if Sinovel Labs will be in the next seven years I also guarantee that you are partners of Zeneca and enjoy the treatment of a first-class laboratory." Arnold once again proposed a condition that other companies could not propose.

In fact, he still has a lot of conditions to talk about, such as price, such as authorization, but he does not want to fall into a price war. The relationship between the two parties is Arnold's biggest bargaining chip, and the scale of Zeneca is his biggest reliance.

It has to be said that Yang Rui was a little moved.

The seven-year partnership and the treatment of the first-class laboratory are really nothing to talk about, and,

Yang Rui believes that Arnold can fulfill his promise.

The development of new drugs, especially the development of original drugs, is extremely difficult, and it is getting more and more difficult. In the 1950s and 1960s, pharmaceutical companies were keen to develop antibiotics, and they almost turned over all the bacteria in the soil. Schools such as Harvard even launched a campaign to let everyone post the soil near their homes. At that time, antibiotics It is not difficult for larger pharmaceutical companies to develop more than a dozen new drugs a year at the rate of several types per month. However, in the 1970s, with the development of technology and stricter drug supervision, single-digit new drugs have become the norm . As far as Yang Rui knows, after 2010, the time expectation for large pharmaceutical companies to develop new drugs has extended to 10 years - if a new drug can be developed in ten years, it will be considered fast.

With such a background, the patience of pharmaceutical companies is actually very good. Not to mention a young and experienced scholar like Yang Rui, who is just a little famous professor from a famous school, the patience of pharmaceutical companies can last for two or three years just after setting foot in this field. Years, or even three or four years.

Seven years is beyond the patience of a normal company, but with the support of Arnold and the support of world-class achievements, Yang Rui is indeed qualified to get such a promise.

However, Yang Rui didn't want such a promise in his heart.

If Yang Rui is an ordinary scholar, he should welcome the inseparable relationship. Large multinational pharmaceutical companies are the best partners in the field of biology and medicine. Of course, they will still bully others with their power, but that does not mean Small pharmaceutical companies don't do that. The only difference is that the big pharmaceutical companies are better-looking, more patient, more funded, and have stronger capital and execution capabilities.

It's a pity that Yang Rui is not an ordinary researcher. There are too many things in his head, which can't be eaten by more than one Zeneca, or any partner.

At the current speed, developing a new original drug in two months may seem like a coincidence or even a fantasy to others, but for Yang Rui, this is indeed a job that can be replicated.

Yang Rui can do what those generic drug companies do after the original drug information is disclosed.

The only problem is that original drugs are far more complex than generic drugs.

Zeneca has a market value of nearly 100 billion yuan and annual sales of over 10 billion yuan. However, in terms of new drugs, it is not bad to have three new drugs each year. Moreover, it may be a new drug composed of different compounds with the same target. Just like Yang Rui’s deferiprone left seven active substances in the end, if these seven active substances pass the clinical trials, it means that there are seven new drugs.

This is also the reason why deferiprone is valued by many companies. The sales of deferiprone itself may not be high, but it has a great chance to pass clinical trials and go on the market, which is enough for various companies to focus on.

Yang Rui's future work will only attract more and more attention, but the scale of Zeneca cannot be expanded rashly.

In fact, pharmaceutical companies often encounter similar situations. For example, there were too many compounds synthesized that year, or too many targets were found that year. What should I do? That's great, I'll do it again next year.

From the company's point of view, this behavior is called technical reserve.

When Wall Street evaluates pharmaceutical companies, stockpiling drugs is also a very important part. Moreover, not only synthetic compounds can be stored, but also how many phase III clinical trials, how many phase II clinical trials, and how many drugs that have passed animal experiments can also be used as a reference for storage and evaluation.

But at Yang Rui's speed, he doesn't want his invention to be reserved by the company, even if the research after the reserve is more profitable, Yang Rui is not happy.

He needs a large amount of money, even a sky-high amount, but his goal has never been purely to make money.

Yang Rui is destined to find a partner other than Zeneca.

If Arnold's promise is fulfilled, or if deferiprone is on the market, Zeneca will not let Yang Rui out easily.

By that time, Zeneca will definitely strengthen its relationship with Yang Rui, which may generate a lot of short-term benefits, but that is not what Yang Rui wants.

Arnold must not have guessed that it was because of his promise that Yang Rui made up his mind.

"I believe your words, but Hua Rui wants to rely on himself." Yang Rui clearly rejected Arnold, then opened a bottle of beer, filled the glass in front of Arnold, touched the beer bottle lightly, and said: "Respect Do your job."

"Respect, everyone does their duty." Yang Rui raised his glass to the others again.

"Regard each of you for doing your duty!" Everyone raised their glasses one after another.

Raymond of the Greenstone Corner Company drank the beer in one gulp. These business elites from developed countries are indeed very proud of "diligence". If they were not due diligence, who would sit on the streets of a foreign country, eat the offal of cattle, sheep and pigs, and smell the rotten smell of stinky tofu.

"How's the taste?" Yang Rui munched his stew, then pushed his belly to the middle of the table, and said, "These two are my favorite Beijing snacks, so you're welcome."

The elites each caught a piece of their stomachs and gritted their teeth vigorously.

After a while, the Japanese raised his head first, with tears in his eyes and said: "It's very delicious. Chinese food is profound and delicious."

Raymond also raised his thumb, his eyes sparkled, and he choked up and said, "Chinese food is amazing."

"As long as you like it, as long as you like it." Yang Rui put down his chopsticks with a smile.

The others hurriedly dropped their chopsticks, and the Italian took a deep breath, then pinched his nose suddenly, his eyes widened.

"Stinky tofu doesn't smell very good, but it's delicious." Yang Rui explained with a smile, and said: "China, like other countries in the world, has many characteristics of its own, and Chinese people also have many habits of their own. But there are similar problems all over the world, and the biggest problem, in today's world, I think, is disease."

Yang Rui pointed at himself, then at the Americans, and said with a smile, "The Cold War should no longer be a hot issue."

"Maybe Reagan cares, but I don't." Raymond smiled.

"I don't care either, but what I care about is whether deferiprone can be launched smoothly and as soon as possible." Seeing that Yang Rui finally got to the point, the others straightened up.

"Would you like to hold a small auction?" the Italian asked.

"No, no, what I want now is not competition, but cooperation." Yang Rui shook his head again and again, "It's just what I said, I hope that desferiprone can be launched smoothly, and it will be launched as soon as possible, so I ask to buy it. An ironone company must be strong and have a strong ability to market drugs.”

Representatives of several companies looked pale.

Strong drug marketing capabilities are not something to talk about. If there is an evaluation standard, a company that has new drugs on the market every year is a company with strong drug marketing capabilities, just like a film company that produces new movies every year. It can be called a powerful film production company.

And there will never be many companies that can do this.

More than half of the companies present here are not strong.

"Please be calm." Yang Rui's smile was contagious. He raised his cup again and said, "I know that different pharmaceutical companies have different business models. For example, some companies are good at drug development..."

He looked at the Englishman and the Norwegian.

"Some companies are good at marketing." Yang Rui looked at American Raymond.

"Some companies are good at developing new indications for existing drugs." Yang Rui looked at the Germans and Japanese.

"Some companies are good at..." Yang Rui looked at the remaining Italians who were eager to try, and said, "Be good at some other jobs..."

"But no matter what." Yang Rui clapped his hands fiercely, and said with a smile: "The launch of a new drug is a big project. I respect your business methods, but I will choose the company or company combination with the most listing capabilities."

Except for the Italians who are still confused about what "other" is, other companies have figured it out.

Raymond asked, "You want you to join forces and buy the patent on deferiprone?"

"It's your freedom to unite or not. But for companies that are more capable of going public, I am willing to transfer some of the benefits." Yang Rui paused, and said: "We can bet against each other.

Now, representatives of various companies are interested.

The pharmaceutical industry is one of the industries most closely related to finance. Those M\u0026A agreements costing tens of millions or hundreds of millions require the participation of investment banks. Tens of billions of sales revenue requires the intervention of commercial banks.

The VAM agreement is the most common contract in the development of new drugs.

It can even be said that VAM is an inevitable contract in the development of new drugs. In the process of new drug development with such a low probability, scientists and laboratories bet against each other, laboratories and biotechnology companies, biotechnology companies and pharmaceutical companies. Pharmaceutical companies can also gamble with Wall Street. Layers of gamble agreements can help professional companies lock in profits to the greatest extent, just like commodity distribution companies use futures trading to lock in risks.

Of course, the reason why everyone likes the VAM agreement is often not because of locking in profits. More people simply like to gamble, just like many commodity distribution companies silently modify futures value preservation transactions into futures value preservation and appreciation transactions.

For pharmaceutical companies that are in an advantageous position in the VAM agreement, they can choose to sell the higher-risk VAM items to Wall Street, and keep the lower-risk and higher-profit VAM items for themselves.

Yang Rui's request is equivalent to guaranteeing the profit of the pharmaceutical company.

Everyone likes a guaranteed profit.