Rebirth of the God-level Xueba

After talking about Wu Hongbo, Yang Rui's plan couldn't have been smoother.

If you look down in the domestic biology field, there are too many people. Just the biology teachers in ordinary primary and middle schools don’t know how many people are needed, but when you enter the scientific research field, especially when you look up, the number of people at the top of the pyramid is very small. .

Wu Hongbo started to show up, and with such a wonderful reward as a trip to the United States, Huarui Laboratory quickly sent out six invitation letters.

At the same time, Yang Rui continued to communicate with several pharmaceutical companies, and actively communicated with Benjamin Law Firm.

The content of his communication was mainly about the PCR lawsuit, and the price negotiation involving deferiprone was inevitable.

As a named partner of a well-known law firm, Benjamin litigated for Sinovel and DuPont, not only for the $2,000 per hour legal fee, but also for more business.

A high-value contract like a landmark VAM agreement has always been a favorite of lawyers.

The milestone contract is extremely complicated, coupled with the existence of the VAM agreement, if you don't pay attention, you will be tricked. Pharmaceutical companies, like financial companies, are inherently evil and never trustworthy. Lawyers are naturally indispensable.

In a few days, almost all pharmaceutical companies accepted the milestone VAM agreement model, and then began lengthy detailed discussions. Some companies also considered whether to establish a joint venture subsidiary to bear the burden according to Yang Rui's request. This work.

In fact, the cost of developing new drugs is too high for some medium-sized pharmaceutical companies to bear independently.

The average development cost of the first clinical phase is US$1 million, and the milestone requirements range from US$1 to US$55 million, which means that pharmaceutical companies may have to prepare a budget of more than US$56 million for this—although they cannot give as much as Yang Rui wants How much, but the budget still needs to be prepared to be eligible for competition.

The average development cost of the second clinical phase is US$20 million, and the milestone requirement is US$20 million to US$60 million, which means that pharmaceutical companies may have to prepare a budget of more than US$80 million for this.

The average development cost of the third phase of clinical trials is US$100 million, and Yang Rui’s required milestone is US$30 million to US$90 million, which means that pharmaceutical companies may have to prepare US$190 million for this.

As a milestone project, the maximum budget of the entire project may reach 330 million US dollars, which is not cheap in any case. Even if the price is too high to pay back the money, at most one-third of the budget will be cut off, and the final cost will still be 200 million U.S. dollars.

This is actually the average development cost of a common drug.

Of course, the pharmaceutical company's cost of 200 million US dollars is a phased expenditure, which also means that Yang Rui's income will also be phased.

The easiest place for him to get money is the milestone of the first clinical phase. As long as the safety clinical trial is passed, he will get at least 10 to 20 million US dollars, and as much as 40 to 50 million US dollars. As long as the contract is signed, the money will almost certainly be available within half a year.

As for the second and third phases of clinical trials, the delay will be longer. If the pharmaceutical company decides to sell desferiprone directly after completing the first phase, it may take longer. And its income is not necessarily more than that of the second period. In fact, as far as Yang Rui knows the established facts, the money obtained in the second period may be less than that of the first period.

Because starting from the second phase, a lot of risks and costs are actually gathered on pharmaceutical companies. And Yang Rui's contribution to the animal experiment was mainly fulfilled in the first clinical phase.

According to the usual process of pharmaceutical companies, it usually takes three to four years to complete the second phase of clinical trials. It is not surprising that it takes five or six years to complete the second phase. If it is done quickly, it is rarely shortened to less than two years.

The third phase of clinical trials is still far away. The development cost of 100 million US dollars is mainly caused by the scale of 20,000 people. The average cost of 5,000 US dollars per person cannot be said to be enough. The 20,000 people were not randomly found by running around, but they all needed to be approved or even introduced by doctors, and they could only be carried out in batches after signing complicated contracts. Its degree of difficulty is even more difficult than promoting a marketed drug. Only the largest marketing pharmaceutical companies can easily carry out this kind of work. Smaller pharmaceutical companies have to mobilize all their efforts to start a business again. Row.

Yang Rui's gaze was mainly focused on the first clinical phase. All the seven compounds in the first clinical phase passed, and he could get the most part. If he was lucky, he might get 40 to 50 million. As for the second and third phases, he will get two 30 million US dollars at most.

Of course, the final listing will also give him a generous bonus-like milestone, which may reach a scale of tens of millions of dollars, but it will take longer, maybe not even ten years.

"Time is really the least durable commodity." Yang Rui couldn't help but sigh when he looked at the schedule given to him by Benjamin Law Firm.

"For you, in the days to come, just wait and count the money. Hey, if I had known that doing scientific research can make money so much, I would not have gone to law school." Hong Kong lawyer Yue Ting gradually replaced Huarui. The little lawyer with a sense of presence has officially become Huarui's corporate lawyer, so he knows some of the relationship between Huarui and Yang Rui. Looking at the documents sent by Benjamin Law Firm at this time, he is even more emotional.

$600 an hour is expensive, but earning $10 million is still out of reach.

Thinking about how Yang Rui easily got the first ten million dollars in his life, yet he was only in his early 20s, and he was still in a closed continent, Yue Ting was filled with emotion.

Yang Rui just smiled and said, "I care more about getting the money than counting the money. You should complete the contract with Zeneca as soon as possible, and sell the coenzyme Q10 catalyst first."

"OK."

"Have you booked your flight to America?"

"PCR's lawsuit is the first priority, and this must be handled well."

"No problem, Benjamin also attaches great importance to PCR. This lawsuit is well-known in the American judiciary and scientific research circles, and the business community and Wall Street are also very concerned."

"Of course they are concerned. Small companies and big consortiums, if I hadn't made sufficient preparations, I wouldn't know how to die." Yang Rui is also paying attention to the US lawsuit situation at any time, but the more he pays attention, the more frightened he becomes.

The huge DuPont consortium naturally didn't come here for nothing.

They actually have a chance of winning. Yang Rui finds it unbelievable when he thinks about this kind of thing. I made the PCR, but it is possible for DuPont to win.

However, this is the law in the United States.

DuPont used two Nobel Prize winners and a large amount of scientific research evidence to make a way out abruptly, proving that he had relevant research since the 1970s.

Never mind, they really do.

It was also Yang Rui who published an article before, did a pre-research on heat-resistant polymerase, and a large number of video tapes, and also invited Nobel Prize winners, coupled with the joining of a large patent law firm, made Yang Rui stable. situation.

Even so, the debates and several court sessions between the two sides lasted for more than half a year, which actually aroused quite a lot of discussion in the industry.

Therefore, Yang Rui had to add money to Benjamin Law Firm, which slowly increased the budget of the lawsuit to nearly 4 million US dollars.

For the Chinese, this is indeed an astronomical figure. Yang Rui privately thought more than once that if he hadn’t predicted the future of PCR, had accumulated enough funds, and made adequate preparations, this lawsuit would have really There is no need to fight on.

$4 million is not the final cost, nor is victory a given. Think how depressing it would be if you spend more money and end up with a loss or settlement.

With so much money, if you take the trouble to convert it into RMB, you can get more than 30 million yuan, which can be used to buy a house in Beijing, and you can buy hundreds of courtyard houses. After 30 years, you can easily sell it for tens of billions of yuan.

Maybe not as much as PCR's $3 billion value, but that's a lot simpler.

After all, to realize the PCR value of 3 billion US dollars, it is still necessary to pay and operate. It is much simpler to put the house there.

Why Chinese companies are unwilling to go to the United States to file a lawsuit, and why Chinese state-owned enterprises would rather suffer losses than protest, can be understood by doing economic calculations. If the top leader of a pharmaceutical company spends 4 million US dollars in a lawsuit and loses the case accidentally, then his official career will be ruined. Even if he wins the battle, he will probably stop on the official road.

However, the rights and interests of PCR are wholly owned by Yang Rui, so Yang Rui could only grit his teeth and sign the check book and hand it to Yue Ting.

Yue Ting carefully checked the signature and spelling, and said with a smile: "No problem, I will deposit it in the company in Cayman."

The offshore company in the Cayman Islands is Sinovel's superior company, and above the offshore company in the Cayman Islands, there are also multi-level offshore companies that together help Yang Rui control Sinovel while hiding himself.

"I'm begging you." Yang Rui put down his pen and said with a speechless smile, "I never thought about more than 1 million US dollars as legal fees."

"Lawyer Benjamin's fee is high, but it's really powerful. Hong Kong companies usually don't have such a lawyer in the United States." Yue Ting smiled and said: "Recently, we'd better keep in touch. I will report the quotations of various pharmaceutical companies to you at any time, so you can inform me when you make a decision."

"Okay." Yang Rui nodded: "I'm not at Peking University in the past few days, but I'm in Huarui Laboratory."

"The scope of Peking University is too wide. It's better to be in a place with a telephone."

"The ion channel lab has a phone, but if I go to class, or stay somewhere in the dormitory, there's nothing I can do."

Yue Ting pondered deeply. From his point of view, it is really important to find Yang Rui in time. He can negotiate on behalf of Yang Rui, but important issues cannot be decided for Yang Rui. If it takes hours to find someone every time, The progress of the negotiations can be imagined.

If a guy like Arnold appears again and gives an hour to make a decision, Yue Ting doesn't know what kind of loss it will cause.

After much deliberation, Yue Ting slapped his forehead and said, "Can we get a pager? A pager is a bit like a phone, but it can only call people in one direction. When you see the number, you know someone is looking for it. The machine is not very big. , smaller than a slap..."

"BP machine?" Yang Rui was even more surprised than Yue Ting: "You have it now?"

"There is someone with this name, do you know?" Yue Ting shook his head for a moment, and answered Yang Rui's question directly: "I heard people say that Shanghai @海 just set up a public paging network this year, and Beijing @Beijing is doing it. , I don’t know if it’s done well, but some units have their own paging stations, such as hospitals and customs, I wonder if it’s possible to join a self-organized wireless paging network through people?”

Yang Rui looked at Yue Ting with weird eyes, and said, "You know more about technology than me."

"Where is it, I am more concerned about things that can save time." Yue Ting smiled foolishly.

Yang Rui complained in his heart: "I mean the technique of pretending to be aggressive."

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