Rebirth of the God-level Xueba

eight pm.

Dean Liu came in a hurry on a bicycle and showed the work permit and letter of introduction to the instructor at the police station.

Also came Li Zhangzhen,

The instructor at the police station suddenly realized: "I said you look familiar, but you are Yang Rui. I heard that you will win the Nobel Prize?"

"It's nothing." The nominations haven't come out yet, so Yang Rui naturally won't admit it.

"I'm sure I remember correctly, it's just some kind of award." The instructor patted himself on the head: "Look at my dog's memory, I can't even remember where the shit is buried."

Yang Rui looked at him speechlessly, and thought: You can eat the things you buried yourself, so don't dig them out to treat guests.

The aunt of the neighborhood committee still didn't quite believe it. She stared at Dean Liu's work card for a long time and said, "Just such a young man, is he from Peking University?"

Dean Liu smiled: "Yang Rui is a student of our Peking University, he must be a young man."

"Such a young man, you let him out to talk to foreigners? You have such a big heart." The aunt of the neighborhood committee said, and then scolded: "Talk about things, talk about things, and find a good person to talk to foreigners. What’s the point of talking? It’s not easy to talk about it. The bullshit is flying all over the sky. What’s the use? We, China, just let you mess it up, let foreigners hear it, hey, it’s all bullshit..."

The aunt was rambling on, and Dean Liu could only stretch his neck to listen, what else should we do? Fighting fiercely, he may not necessarily win, and it is definitely not good to roll up his sleeves to fight. If you want to find the police, the instructor of the police station will stand by.

After being sticky for half an hour, Yang Rui and the others escaped.

A few foreigners are very excited, and they all think it is a rare life experience. There is a feeling of overlooking piranhas after swimming in the Amazon River, watching drug dealers on TV after passing through the slums of Mexico City, and boarding a plane after graffiti in Pyongyang The joy of gazing at the statue of the leader.

However, there is no way to continue the negotiation. In fact, it is unnecessary. The conditions discussed above are also in the nature of notification. In the end, whoever is willing to sign the contract, who can agree to Yang Rui's conditions, or who wants to bargain, will have to follow up Then decide, and even the CEOs of the companies and even the board of directors will decide. After negotiating such a VAM agreement, the minimum situation is to pay 1 million US dollars and get nothing. It may also pay 20 million US dollars or more to get more than one active substance to pass the first clinical phase. Of course, it may also be to pay Tens of millions or even 100 million US dollars can get a drug that has passed the second phase of clinical trials.

If it is 1 million US dollars, the few present can naturally decide, but everyone is not running for a loss. Since the amount involved in the contract may be hundreds of millions, it must be approved by someone with such authority. Naturally, it cannot be done on the spot. decided. literary age

Of course, although no decision was made on the spot, or even a paper agreement was signed, everyone present was very happy.

In addition to one more experience, Yang Rui's performance also increased their confidence in deferiprone.

It is true that deferiprone is not a blockbuster, let alone a big killer like penicillin. However, my God, how many practitioners in the entire pharmaceutical industry thought that they could sign a new penicillin? ——Perhaps when you were dreaming, you had such a beautiful dream, but when you wake up from the dream, you have to face reality.

It’s like the dream of all architects to build the world’s number one building. Everyone can make this the goal of lifelong struggle. Who can sign a contract every time they do a design? That’s the requirement?

In the same way, everyone knows that blockbusters sell more than US$1 billion a year, and one of them can make a lot of money, playing Porsche and Ferrari every day, but when signing a contract, you can't just focus on blockbusters.

Lobster is delicious, but you can't just eat lobster.

In this era when the entire industry can only produce double-digit new drugs every year, you must hold lobsters in your hands, and you must not let go of steaks. Even if you hold lobsters in your left hand and steaks in your right hand,

If you see a steamed bun, you have to step on it, otherwise, who knows if the lobster and steak will be eaten, or the fda will have a brain twitch and suddenly bury the lobster and steak? This kind of thing happened not once or twice, otherwise, Wall Street would not value the pharmaceutical company's drug storage capacity so much.

Because of this, in this industry, original drug companies do most new drugs with the same target. For example, in order to treat chronic myeloid leukemia, biologists found that targeting the molecular target bcr-abl may have a therapeutic effect, so , the laboratory of the pharmaceutical company conducts high-throughput screening on this, produces 30 to 50 active substances, and starts the step-by-step animal experiments and clinical trials. Finally, imatinib appears and seems to have achieved the expected goal, then , Has this target completed the task?

Of course it's impossible, this just shows that the molecular target bcr-abl is indeed as effective as biologists said, so more pharmaceutical companies will get involved in this field, so dasatinib and nilotinib have one after another Birth, the relationship between these drugs is like the relationship between the last seven compounds left by Yang Rui.

If the seven compounds produced by Yang Rui finally pass the clinical trials, then theoretically, seven deferiprone drugs can be produced.

In fact, such a situation often occurs in pharmaceutical companies. It is very common for two or three compounds or even more compounds to pass clinical trials. This is not a bad thing. For pharmaceutical companies, on the one hand, they can choose The best compounds are made into drugs. On the other hand, they can also register a generic drug by themselves when the patent protection period expires, or even register multiple drugs by themselves during the patent protection period, thereby occupying the market and raising the threshold .

Because the pharmaceutical industry is inherently profiteering, so even if you earn less, you can still make 20 to 30% of the profit. The benefits of new drugs with the same target are lower risks and faster return of funds, so they have become the most popular pharmaceutical companies in the pharmaceutical industry. first choice.

At first deferiprone was not taken seriously, not only because of its status as a rare drug, its expected sales volume was low, but also because of its status as a purely original drug, its risk was high and capital return was slow.

The former is a relatively difficult situation to change, but the latter has now been changed by Yang Rui.

The seven active substances that have passed animal experiments reduce the risk of passing clinical trials, and Yang Rui is willing to sign a VAM agreement, which further reduces the risk.

In fact, original drug companies are not afraid of high costs, they are more afraid of risks.

As long as the risk is low, 60 million or 100 million, they don't feel much.

Now the cost of new drug development is rising steadily, 200 million 300 million is very common, and it is still done under the circumstances that the bottom cost is very expensive. Yang Rui's gambling agreement is actually in line with the expectations of pharmaceutical companies.

However, the gentlemen of the pharmaceutical company are happy, but Dean Liu is not happy at all.

He handed the bicycle he rode over to a Zeneca employee, got into Zeneca's car himself, and asked them about the content of their negotiations.

Yang Rui selectively told him a few things. Before he could talk about the price for the second clinical phase, Dean Liu let out a long sigh:

"I remember you asked us before, do you want to do deferiprone? This is the deferiprone." Dean Liu asked regretfully.

Yang Rui nodded: "If you refuse, I will cooperate with Huarui Lab."

"That is to say, if we had agreed at the time, it would be possible to recover tens of millions of dollars now?"

"Not necessarily. If I sign this agreement, I may not get a dime, but it is possible to get back tens of millions." The gambling agreement is not mandatory. If Peking University owns deferiprone For patents, the most likely way to sign a contract is a milestone direct authorization, so there is a chance to recover 20 to 30 million, or 40 to 50 million.

Dean Liu selectively ignored the part of "you can't get a dime", looked straight at Yang Rui, and said: "We missed pcr, and we missed deferiprone, Yang Rui, you can't do it all Good things go to Huarui."

Yang Rui shrugged, and said, "I've asked you about these two things, and you don't want me to give Huarui."

"You should persuade us more."

"No matter how good I say, the funding is real. It's the funding that persuades you, right?" Yang Rui said: "PCR cost more than one million US dollars at the beginning, and deferiprone is even higher. Now it's a waste of money. A few million dollars is good luck. If you are not lucky, twenty to thirty million dollars is worth it, and Peking University can’t afford such a large amount of funds. I’m talking about hype, and the project will still be yellow.”

When he was doing PCR, Yang Rui asked in a hypocritical manner. If Beijing University really wanted it, he would rather drop out than give it to him. However, the situation with deferiprone is different. If Peking University is really willing to take this risk, Yang Rui is willing to take out deferiprone. Because the risks do exist, before Yang Rui did it, he was not sure how long it would take to make it, let alone the result and cost of making it. Maybe in the end, it will really take a year or two, tens of millions of dollars, and it is also possible.

If Peking University can fully invest, it will naturally provide more and more professional pharmaceutical industry experts. Yang Rui can not only save time to do other things, because deferiprone brings a lot of prestige and honor.

Of course, now that things are done, it's useless for Dean Liu to say anything.

Dean Liu himself knew this, shook his head, and said, "No, if you have a new project, you have to explain it to us."

"That's for sure." Yang Rui said something truthfully, and then asked again: "Can you afford projects that require a lot of funds?"

"It depends on how much." When it comes to the funds, Dean Liu is still a little timid, turning his head and said: "Let's talk about deferiprone first."

"Didn't you just say that?"

"You just talked about the negotiation, the cause and effect, and didn't talk about the specific research."

"Ah... so how long will it take?"

"No hurry, let's go back and talk slowly." Dean Liu said, patting the back of the driver's seat in front of him, and said, "Go to Peking University."

"Now?" Yang Rui looked at his watch, it was already past 8pm.

Dean Liu said unambiguously: "Go, Academician Cai and the others are waiting. The research on new drugs has just started in our country."

As he spoke, Dean Liu scanned Yang Rui up and down with his eyes.

Yang Rui felt uncomfortable being swept away, and asked, "Can't everyone wait in the office? When I called you, everyone was off work."

"It's off work. Everyone is gathering at Academician Cai's house. My sister-in-law is cooking. Let's drive faster and make some soup." Dean Liu said and urged the driver.

.........