Rebirth of the God-level Xueba

Yang Rui’s visit to Zeneca and other companies was very short, but it was enough for them to understand the working conditions of the laboratory.

This is also a very important point. The experimental data of third-rate laboratories are unreliable, just like the articles of many unknown scholars in unknown universities, which are rarely cited by anyone. The main reason is the credibility issue. Scholars read these articles more to provide a way of thinking. When they really need data, they will still do it by themselves before rest assured.

The data obtained by deferiprone in Sinovel's laboratory is very good, so Yang Rui let them know Sinovel's laboratory first.

As for the specific data, etc., there is no need to release it.

What others see is a simple collection of data.

But these data collections are enough for representatives of various companies to ponder for a long time.

At the end of the visit, Yang Rui took Grace, Wei Zhenxue, Wang Xiaoyun and other people from the pharmaceutical team, and sent the company representatives out of the door in a friendly manner.

Watching a car start and then slowly leave, Grace laughed rarely.

Wei Zhenxue looked at Grace's smile inexplicably, and asked, "Do you also like watching car exhaust?"

Wang Xiaoyun habitually helped Wei Zhenxue translate.

Grace frowned incomprehensibly: "Yeah?"

Wei Zhenxue could understand the words, smiled "Oh", and said: "I don't mean that I like to watch car exhaust. I don't like watching car exhaust, but Bao Si likes it. Have you heard the story of the princes in Fenghuo Opera? There is just one Women like watching fireworks and the Great Wall..."

"Old Wei." Yang Rui was stunned, and sighed, "You really are so annoying."

Wang Xiaoyun was also dumbfounded, and belatedly stopped translating, and said, "Old Wei, it's fortunate that you don't understand English, otherwise, you would be smoking in the afternoon."

"What do you mean?" Wei Zhenxue didn't understand.

"Cremify your smoke." Wang Xiaoyun's voice was stern.

Wei Zhenxue was not affected at all, and said with a smile: "Impossible. We have a rule in our hometown that you have to stop for seven days before you die. If I die today, you will burn it for me today? You are too bad, fortunately, you are not my wife. "

Wang Xiaoyun said angrily: "I'm a bad person? You don't want to ask why you died?"

"No need, we are not afraid of death, don't study chemistry if you are afraid of death, don't you think so?" Wei Zhenxue made a resolute expression, matching the facial features on his big face, like a death squad from the puppet army.

Grace looked blankly at the two people who were speaking fast, and asked Yang Rui in surprise, "They were talking to me just now, right?"

"Yes."

"Why did you stop talking halfway through?"

"Hmm..." Yang Rui didn't know how to explain a story about a normal person who was so funny that he pissed him off.

"Did I do something wrong?" Grace felt that Yang Rui's expression was very familiar, and said, "I often make people angry, it's okay, just tell me what's wrong."

"It's not your problem." Yang Rui didn't bother to explain, and said directly: "Just now you watched the people from Zeneca leave and laughed, why?"

"I wonder how they'll bring it back after they've assessed the prospects for deferiprone." Grace smiled slightly again.

"The profit of deferiprone will not be too high,

After all, deferoxamine exists. "

"For a drug that has just been tested on animals, the most important thing is how far it can go through clinical trials." Grace finished, and then said: "I hope you can choose a suitable company to sell it instead of Pick the one with the highest offer."

"kindness?"

"Although the companies with the highest bids may be the most interested, this does not mean that they have the strongest execution capabilities." Grace said: "It may take only two or three years for a suitable company to complete the clinical trial of deferiprone." , an unsuitable enterprise, it may take seven or eight years..."

"I understand. I will choose the most suitable company, even if it doesn't make money." Yang Rui said righteously.

"How is it possible not to make money?" Grace glanced at him and said, "I am the only medicinal chemist in your team, and you don't need a salary. The total development time is no more than three months, even if you include your theoretical research time." , and there is not much cost, you will become a millionaire."

"That's not bad." Yang Rui laughed out loud.

...

the next day.

Van Lundin also made a similar exclamation: "The Chinese are really going to get rich."

Arnold also said with a sullen face: "54 points is indeed a score to get rich."

What they do is clinical candidate drug evaluation, which is to evaluate that a drug has a high probability of passing clinical trials.

Drugs with a high probability of passing will enter clinical candidates, and then have the opportunity to undergo clinical trials.

Different from the intuition of ordinary people, those drugs that may be very effective in treating diseases do not have a strong advantage in the evaluation of clinical candidate drugs. The reason is simple. There are many good drugs, and you must pass the review to make money. , what cannot pass is just a rainbow.

Any drug that gets a high score in the evaluation of clinical candidate drugs means that it has great prospects. Companies like Zeneca and Pfizer like to acquire drugs after the animal experiment stage.

They will spend tens of millions or hundreds of millions of yuan to purchase a drug, and then spend two or three times the price for clinical trials. Once they pass it successfully, they can earn back all the previous payment in one go.

It is also for this reason that three-quarters of the original drugs developed each year in countries around the world are developed on the targets of existing drugs.

Although such original medicines are also original, the degree of originality is not high, but they are very safe.

They are cash cows that can secure profits.

An extreme example is antidepressants, where the FDA has approved no fewer than seven products, each of which has generated over $1 billion in sales.

In any pharmaceutical company, "blockbuster" is an important capital, so that it can be encountered but not sought. In contrast, it is much simpler to make an original drug with the target of the drug as the target.

Deferiprone is different, because the last seven active substances left by Yang Rui have good effects, and their scores are all very high, which greatly increases the chance of deferiprone passing the clinical trial.

And as long as it can pass clinical trials and be officially launched, how to sell it is another matter.

According to Zeneca's evaluation model, compounds with a score of 30 or above can be included in the list of clinical candidate drugs, and those with a score of 40 or above are basically ranked in the forefront. If there is no major problem, clinical trials will definitely be carried out.

As for drugs with a score of more than 50, there may not be a few every year.

Arnold also calculated and calculated, and finally determined that deferiprone had reached the standard of 54 points.

"The patents this guy has applied for are too complete." Arnold didn't know whether he admired or was annoyed.

Big Pharma doesn't mind looting smaller companies by squatting on patents if they can take advantage of them.

For a drug whose annual sales may reach hundreds of millions and itself worth over one billion or even tens of billions, large pharmaceutical companies will do anything.

Franky checked the patent himself, and said: "Yang Rui is still going to sue now, so he must be very concerned about the patent issue."

"I registered the patent of the intermediate, the patent of the preparation method, the patent of the product, the patent of the crystal, the patent of the amorphous form, and the patent of the composition!" Arnold gritted his teeth and said, "He is too insecure. If you don’t, you won’t be able to give people a little more trust.”

Franky thought about the issue of "trust" for a long time.