Rebirth of the God-level Xueba

Fan Lundin looked at the cartloads of rats being transported into Huarui's laboratory, his face uncertain.

Animal experiments, for the development of a new drug, can be regarded as a great progress.

The vast majority of new drugs will fail in the synthesis stage after passing the target screening. For example, if products such as coenzyme q10 are not directly extracted from animal tissues, and enter the market at a high price as health care products, there is no such thing at all. possibility of commercialization.

This is also because the efficacy of coenzyme q10 is not significant enough. If it can really treat heart disease, instead of a small auxiliary effect, pharmaceutical companies from various countries have spent hundreds of millions of dollars to try to synthesize it.

Although the synthesis of organic molecules is difficult, it is nothing more than a doctoral thesis.

Of course, there are some Ph.D. students who can't finish their graduation thesis no matter what, so that they can't graduate in five or six years.

In any case, entering animal experiments means that a large number of chemical molecules have been synthesized, and if they are sold now, they can already earn a lot of money.

Thinking of the bonus that Yang Rui might get, or the bonus that Yang Rui lost, Fan Lundin was in a trance again.

"This Chinese, does he know what he's doing!" Van Lundin thought, if he had the ability to synthesize more than 30 compounds a year, he would already have an annual salary of one million. in the universities of the world.

Yang Rui synthesized so many compounds in less than two months, even if there is theoretical research - this is what makes Fan Lunding even more sour. When did Yang Rui do the theoretical research? Fan Lundin already knows , Yang Rui completed the semi-synthesis of coenzyme q10, the research and invention of the potassium ion channel in the past more than a year, and then wrote a book on genomics...

Fan Lundin had no idea where Yang Rui spent his theoretical research time.

Although many scholars have famous high-yielding periods, such as the famous Miracle Year, this Latin word is used to call Newton’s 1666, when Newton left Cambridge to return to his hometown in order to avoid the plague, and in this year, the exact In other words, from 1665 to mid-1667, Newton constructed calculus, established the law of universal gravitation, and completed the experiment of decomposing visible light into monochromatic light, which was equivalent to reshaping the three fields of mathematics, mechanics, and optics.

The miraculous year of English belongs to Einstein in 1905. In this year, Einstein created the special theory of relativity and published two papers in succession, "On the Electrodynamics of Moving Bodies" and "Is the Inertia of an Object Related to the Mass It Contains?" , In the same year, three other heavyweight papers brought Brownian motion and quantum theory to a new level, any of which was Nobel Prize-level.

Compared with Newton's miraculous years and Einstein's miraculous years, Yang Rui's 1983, or 1983 to 1984 is not worth mentioning. Although strong, after all, it is not as strong as calculus or quantum theory, gravitation and special relativity. It is an immortal work, surpassing more than one order of magnitude.

However, these things are also more than an order of magnitude beyond Van Lundin.

Standing with Van Lundin watching the rat cars come in and out were Franky and Arnold.

When the two heard Fan Lundin's words, they looked at each other and smiled, thinking, of course Yang Rui knew what he was doing.

Franky's butt has been crooked for a long time, and he is too lazy to talk about it. Arnold felt that Fan Lundin still has value, and comforted him: "No matter what Yang Rui thinks, as long as we have achieved our goal."

Van Lundin smiled wryly: "I thought making 20 active substances would be able to drag down the Huarui experiment..."

For a small biological company, if it can produce 20 kinds of backup targeted active substances in three years, it is all luck.

And time, for a biological company, is also a very large cost, which also implies the problem of success rate. Simply put, the cost of the results made in three years is basically three times that of the results made in one year. more than double.

If Yang Rui produces 20 kinds of active substances in three years, the materials and manpower consumed during the period are naturally needed for three years of daily experiments.

However, it took him two months to make 20 kinds of active substances, and it took a lot of money, and it didn't take much material, so how could it be considered as the achievement of the goal.

Arnold originally hoped that Yang Rui would sell the coenzyme q10 catalyst formula because of the ever-increasing scientific research budget, but the result was just the opposite. Yang Rui could completely lower the scientific research budget, making his plan almost bankrupt.

Arnold wiped his face and said: "They are now conducting animal experiments on more than 30 compounds at the same time, which will also increase the immediate cost. You should first stare at them and see the results before deciding what to do. Don't be discouraged."

"Grace has joined Huarui Laboratory. They do animal experiments, and the possibility of achieving results is very high." Fan Lundin backed down.

"You have to continue to play your role and strengthen your guidance. For example, try to improve their standards. Animal experiments are also expensive, and the results will only be seen sooner." Arnold continued to encourage Van Lundin.

Frankie said by the way: "Yang Rui is a fledgling in the field of pharmaceuticals, but you don't just listen to what you say. Don't raise the standard too far, lest he send you back."

Van Lundin nodded silently, and said: "There is no need to make special improvements. I will directly translate the FDA's request to him. Such a team cannot pass the test no matter what."

The FDA has always been criticized by the industry for being too strict. The same drugs that can be marketed in Europe are often not available in the United States.

By the 21st century, this polarization has become so severe that patients in Europe have more than 200 new drugs than those in the United States, so that bringing good European drugs back to the United States has become a business.

Whoever can buy the right to operate a European drug in the United States, and then pass it through FDA's animal experiments and Phase III clinical trials, often means hundreds of millions of dollars in revenue.

Therefore, it is a very high requirement to follow the requirements of the US FDA at the development stage.

Half of the drugs will be disqualified from marketing because of this-Europeans don't want your failed products under FDA standards, they want successful products that can pass their own standards.

After receiving Arnold's clear instructions, Van Lundin didn't even watch the mouse enter the cage, and immediately returned to copy the rules.

On the other side, a large number of mice and rats were locked in a compound not far away.

Yang Rui's Huarui laboratory already had a lot of free land. In order to avoid being taken back by the government, yards were built one after another.

The yard where the mice and rats are held has also been designed, and experimental animals are also an essential configuration for the biological laboratory.

Yang Rui even designed the place where the gorilla will be held in advance.

However, what is needed now are mice and rats.

The little white mouse is cuter. It is bred from Mus musculus. As the smallest type of mammal, the little white mouse has been studied most thoroughly and is also the most convenient for primary experiments.

Rats are white rats, and there are many varieties, including the Chinese brown rat, which is a common house mouse, which is relatively not so cute.

But whether they are cute or not, these mice and rats have to contribute to the development of human medicine and biology.

Strictly speaking, this is a cruel act, but the reality is so cruel.

Animal experimentation for the purpose of making cosmetics is most likely to be attacked by society, especially animal organizations, so that many people initiate activities for not using cosmetics, or "freedom from cruelty", but even girls who love beauty can refuse to use beautiful little white rabbits Nail polish that has been tested for safety, you can refuse the sunscreen, concealer, hydrating body lotion, baby oil, day cream, night cream, mask, aftershave, hair removal cream, which is tested on the skin of a pink pig, but can’t refuse it. Save yourself medicine.

The only thing that can be done is to ensure the necessity of using experimental animals and the living environment of experimental animals.

Grace carefully inspected each cage, and while labeling each cage, carefully fed a small amount of water to the mice and rats, and asked about various indicators in simple English.

Wei Zhenxue graduated from the Department of Chemistry. He has never done animal experiments before, and he is a little afraid of mice. He looked at it from a distance and said sarcasticly: "If my wife treats me so well, I will be willing to let me be a guinea pig."

"Write down these few words, and let's read it in a few days." Wang Xiaoyun laughed twice, and stepped forward to help.

Wei Zhenxue looked at the work status of the two ladies in every detail, and rarely said a good word: "Old Tu is lucky, to marry a wife is to marry such a good wife and mother."

The corners of Tu Xian's mouth twitched twice, he shrank his neck, patted Wei Zhenxue's shoulder with deep feeling, and said, "If the woman in the Department of Biology treats you well, you have to think about her deep-seated purpose."

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