Rebirth of the God-level Xueba

Fan Lundin was very silent in Huarui's laboratory, and rarely chatted or even talked except for some things in the development of new drugs. Sometimes, he would even watch Yang Rui make deferiprone derivatives one after another with resentful eyes. . (Please go to the latest chapter)

Yep, another deferiprone derivative after another.

Yang Rui fully listened to Fan Lundin's opinion and decided to make more derivatives of deferiprone for future use.

The development of new drugs is a test of character, because the public has unusually high requirements for pharmaceutical companies, which makes the risk of clinical trials infinitely increased. Drugs with the same chemical structure that can pass in Europe may not necessarily be approved in the United States. If you pass this year, you may not be able to pass next year.

Even a company like Pfizer cannot guarantee that a drug with a certain chemical structure will pass the FDA's review. Different chemical structures will have different side effects, and everyone's reaction to the drug is different. It is impossible to guess whether your next clinical trial will encounter a stress response from a certain patient.

Modern clinical trials can't cover the whole population, let alone the screening of clinical trials through genes. Therefore, unless it is an important drug that is highly anticipated by the company, a clinical accident is enough to ruin a good drug. future.

As for the solution, it can only be like buying a lottery ticket, buy as many as possible, and try to cover as comprehensively as possible.

Of course, under such policy restrictions, the public's access to drugs is not necessarily the drug with the least side effects and the most outstanding efficacy, but the drug with the best luck.

In other words. Yang Rui is not convinced that the chemical structure deferiprone used by the Indian company must have the best curative effect. And deferiprone with the least side effects.

Similarly, Yang Rui is not sure that the most fortunate chemical structure will still stand out in another clinical trial.

Therefore, after being reminded by Fan Lundin, Yang Rui could only make more active substances as much as possible.

And his method of making new active substances is also very simple. Just copy the generic drug that used to be.

Different generic drugs have different chemical structures. As a generic drug company, if they intend to imitate a certain original drug, they often prepare three to four years or even six or seven years in advance. With such a long period of time, weak generic drug companies can always imitate several similar chemical structures , and then enter the stage of clinical trials - the review system for generic drugs is much looser than that of original drugs. Even so, there will not be too many generic drugs that can pass the supervision.

But for Yang Rui, who has scanned books such as pharmacopoeias, one or two generic drugs appear in a country. There are too many generic drugs in the world, especially the drugs around the 1990s,

The structural patents of generic drugs have all expired, and generic drugs of various generic drugs are emerging in an endless stream. Some of them are quite creative.

Yang Rui doesn't need to think too much at all, just follow the established steps and make all kinds of drugs with different chemical structures in sequence.

This feeling is actually a bit like the work of graduate school, which is nothing more than achieving the established goals.

Although boring, there is actually a slight sense of accomplishment.

After all, it's an average day to make a whole new compound. It's still easy to overwhelm your professionalism.

Think about the fact that ordinary people use iron sheets to hoop a trash can, and they are happy as if they have done a great job, synthesizing a new compound-well, ordinary people don't care about this kind of thing.

Even Wei Zhenxue turned a blind eye to Yang Rui's hacking behavior.

Although he graduated from a chemistry major and has worked in the Institute of Media Sciences for many years, the chemical engineering major in China has always taken the responsibility of absorbing the nutrition of Western countries, and it is better than anything else to use it to make a new compound every day. This kind of thing can sometimes be used as propaganda.

However, Van Lundin has not worked at the Media Science Institute for many years.

He has studied and worked in Cambridge for many years, and he has never seen a brand-new compound so quickly.

Van Lundin couldn't help but call his former mentor. At the end of the call, the two parties listened to each other's breathing for a minute, which was considered to be the end of the conversation.

Since that day, Valentine was still more silent.

Wei Zhenxue asked Fan Lunding a lot of questions because he was helping Yang Rui, but he didn't get an enthusiastic and detailed explanation. He was very upset. Head, as if others owe him hundreds of thousands, it's too painful."

"People don't like to talk." Next to him is Wang Lei, a fierce researcher. He is currently a professional researcher and has been doing odd jobs with Yang Rui for a long time.

Wei Zhenxue shook his head: "Didn't you see how much he talked when he first came to the laboratory? I think he was unwilling to see the results we made, or he was simply jealous, so he didn't speak."

"Where would it be? People who graduated from Cambridge are jealous of us." Wang Lei curled his lips and said, "I heard that the monthly salary of foreigners is tens of thousands of yuan. Don't those who graduated from Cambridge pay more?"

"They graduated from Cambridge, and it's not that Cambridge belongs to them. As far as we make deferiprone, they don't have it." Wei Zhenxue also shook his head, and said: "Tens of thousands of dollars a month is nonsense, it's not like we haven't seen it before." Foreigners, those who have thousands of yuan a month are not old or young. If it is given to me, I will save money, spend 50 a month, save and send money, and when I save 200,000, I will quit my job and go home, eating bank interest every day , don’t need to nest in the laboratory every day?”

Huang Mao, who was doing polymerase experiments next to him, heard it and couldn't help but said: "Old Wei, we work in the laboratory not for money, but for common ideals and pursuits."

"and then?"

"So, you are not hiding in the laboratory because you don't have 200,000, you are hiding in the laboratory for our ideals and pursuits."

Wei Zhenxue stared at Huang Mao for a long time, sighed, and said, "You are wrong, because you are nested in the laboratory every day, so you don't have hundreds of thousands."

Huang Mao was dumbfounded.

Wang Lei let out a chuckle, then quickly covered his mouth, and said, "What I mean is that Researcher Wei actually likes to nest in the laboratory, otherwise, why would he not be willing to go back after get off work?"

Wei Zhenxue snorted, turned his head to look around, and said, "What am I going home for? There is Wang Xiaoyun in the lab, and I only have Huanglian Po when I go home."

Wang Xiaoyun raised her head in surprise when her name was called, and not far from her, Comrade Wang Xiaoyun's husband, Comrade Tu Xian, gently sniffed a jar of liquid to his hand.

Wei Zhenxue saw it, laughed, and hurriedly said: "Old Tu, you have no sense of humor."

Huang Mao laughed, and said, "I think it's quite humorous."

Yang Rui and others also laughed. Liquid smell is a very terrible poison. Its wounds are yellow, without scars or suppuration. It just rots like that. It is worse than sulfuric acid when splashed on the face. It fits the definition of yellow face... This is The reason why a few people laughed is only a joke in the laboratory.

Listening to their laughter, Valentin felt awkward, and when he went back at night, he couldn't help calling his instructor.

"How many active substances have they made now?" the mentor asked Van Lundin.

"21 kinds." Van Lundin's bitterness could be heard through overseas calls.

"In two weeks, from 12 to 21?"

Van Lundin said: "To be specific, it is 11 days, and 9 kinds have been added."

"Not too possible……"

"This is what I want to say... Is there such a possibility? He did theoretical research in advance, a lot of theoretical research... Then, now it is verified through experiments."

"That's too fast. But..."

"But what?"

The instructor on the other end of the phone took a breath and said, "It's not impossible if it's Yang Rui."

"Huh?" Valentin was very surprised. He never thought that his always proud mentor would say that.

"You probably haven't known academia for a long time. Do you know how everyone evaluates Yang Rui now?"

"I know that his recent studies are very famous, and his articles have been published in Cell and Nature, but I don't know the academic evaluation." How could Van Lundin know the academic evaluation of a scholar, He has been away from academic circles for too long.

The tutor in Cambridge said solemnly: "There are many evaluations, and some of them said something that I didn't believe before."

"Huh? What are you talking about?" Valentine had the feeling of watching a horror movie, and the goosebumps all over his body stood up.

His mentor's voice was more slow and heavy: "Some people say that Yang Rui will win the Nobel Prize sooner or later, and maybe he will win the Nobel Prize very early, so that he will break the Nobel Prize in Physiology and Medicine." I didn't believe it at first, but now it seems that it is really possible."

Valentine's body trembled with a "huhu".

The word Nobel Prize is more exciting than a room of gold to academics and researchers in the industry.

A person with a Nobel Prize may be able to mobilize more resources than a person with a room full of gold.

And that sense of honor is irreplaceable.

"I can ask a few people for you to see if there are any scholars who know about norferiprone. It is a rare opportunity for you to learn more from Yang Rui." The instructor paused, and then said: "Last month, our laboratory It is a simple but easy-to-use instrument, a cross-age invention.”

... (To be continued.)

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