Rebirth of the God-level Xueba

Chapter 1373: Enzyme Substitution

"Grandpa, please ask me, Director Yang is here. ?? Read a book WW?W?K?ANSHU.COM" combing the three-seven-point translation, came to the door of the ion channel laboratory, with a smiling face, gave The concierge, Uncle Qin, offered him a cigarette.

Uncle Qin took it unceremoniously, looked at it, and found that it was all in English, so he put it in his mouth, and said vaguely: "The conditions are good, and foreign cigarettes are affordable."

The translator quickly lit the cigarette for him, and said with a smile: "If you work for a foreign company, you have to put on a front."

"Well, the taste is strong enough, with the strength of a cigarette pot." Uncle Qin commented.

The corner of the translator's mouth twitched twice, and he thought to himself: If you want to smoke the pot, tell me earlier, I'll just weigh you a catty of loose cigarettes.

Uncle Qin inhaled one-third of the root in one breath, spit it out, nodded comfortably, and said again: "Which unit do you work for? What can I do with Director Yang? Have you made an appointment?"

While asking questions, Uncle Qin unfolded the registration book, pushed it in front of the translator, and said, "Foreigners also need to see their certificates. We are a confidential unit here, you know."

"I know, I know." The interpreter glanced at the police box next to him, and the armed police soldiers who did not know when they came, and asked in a daze, "When did the armed police stand guard in our ion channel laboratory?"

"It costs as much as the sea to make new medicines. Can it be done without sending armed police?" Uncle Qin took it for granted.

In terms of the value of new drugs, the cost and profit of tens of millions of yuan is indeed more than most of the state-owned enterprises in China. It is not out of the ordinary to send an armed policeman to stand guard. I can't understand the translation.

Fortunately, the foreigner didn’t understand even more. After the translator filled out the registration form, he turned around and smiled at the customer: “Mr. Leander, the Ion Channel Laboratory of Peking University is a government-funded laboratory. They sent the police just to ensure its safety. Restricting the entry and exit of foreigners will not affect your stay in China."

"Are you sure?" Leander is a yellow-haired foreigner with gray hair. His eyebrows protrude an inch from his forehead, and they are carefully trimmed.

"I'm sure." The translator gritted his teeth and gave an answer. He was afraid that the foreigner would turn his back on his voice, and hurriedly said: "Director Yang is in the laboratory now. I just registered, but we are ranked sixth today. I can definitely see you, I have to call to confirm later, how about I take you to play for an afternoon and come back tomorrow?"

"Mr. Yang Rui must be very busy right now, please confirm with them again, I really want to cooperate, maybe we can meet in advance." Leander spoke as slowly as possible, so that the translator could understand what he said.

The translator was stunned for a moment, and smiled: "Okay, then I will discuss it again, but people said that today is out of time, and Director Yang will not receive guests today. ?W?W?W?·?K?Ashu NSHU ·COM”

Leander nodded silently.

The translation was a little weird, but I was inexplicably proud. Although it was easy to cheat foreigners out of money in the past, after all, they were called and drunk, and they had to endure foreigners’ unreasonable interpretations of Chinese culture and history. The Chinese, he is just a middleman, but feels excited.

After asking two more specific questions, the translation was in front of the concierge. After muttering for a long time, he turned around and asked Leander, "Would you like to meet Yang Rui with the others?"

"See you together?"

"I said you are the manager of a pharmaceutical company,

The other party said that if they are willing to work with the managers of other pharmaceutical companies, they can advance, otherwise, they will have to wait. "

Leander looked suspiciously at the concierge, Uncle Qin, and asked, "Does he have the right to make this decision?"

"Maybe it was decided long ago in the ion channel lab."

"Okay, if we meet together, can we see Yang Rui today?"

The translator shook his head slightly, and said, "It can only be tomorrow afternoon. Or, let me take you to the Forbidden City to have a look. There are many Chinese antiques and cultural relics inside."

"What would Mr. Yang Rui like? Let's go buy something he likes." Leander said purposefully.

The translator opened his mouth, nodded, and said, "Then let's go to the Friendship Store."

Afternoon the next day.

Leander ate a simple lunch and arrived at the ion channel laboratory with canned food and malted milk bought from the Friendship Store.

From personal experience, Leander did not believe that Yang Rui would like canned food and malted milk, but the translator said that these are high-end gifts that Chinese people give each other, so Leander believed it. After all, in which country do people have no hobbies?

In the living room, Yang Rui was a little dazed when he received the gift from Leander. These days, there are foreigners who try to bribe, but with canned food and malted milk? The ones bought in the Friendship Store are not suitable either.

"Mr. Leander, please wait a moment." Yang Rui could only put the canned food and malted milk on the table, and told the scientific research dog helping in the conference room to bring it back to the foreigner later.

Leander was very happy, feeling that Yang Rui had accepted his gift, and boldly asked, "Professor Yang, may I ask which other pharmaceutical companies will participate in the talks?"

"Greenstone Corner, GlaxoSmithKline, and Zeneca are sure to participate. Whether the others will come, I'm not sure yet." Yang Rui casually named a few names.

Liandel immediately felt the threat of the approaching enemy.

Both Zeneca and GlaxoSmithKline are behemoths compared to his Calitz pharmaceutical company.

Liandel didn't have much chance to speak, just raised his hand to look at his watch, and several men with blond hair, brown hair or white hair came in.

Yang Rui looked a little funny. Europeans and Americans haven't started playing with diversity yet. So, on both sides of the conference table today, there are all white men, not to mention the absence of people of color, and there is not even a woman.

Pharmaceutical companies in the 1980s were purely patriarchal politics. If it weren't for this, there would be no organized women's public relations projects.

Yang Rui was thinking wildly, and when everyone was seated, he said, "Everyone's time is precious, so I'll get straight to the point."

He uses Chinese, and he has the translator next to him to worry about how to translate straight to the point.

After the latter said a string of English, Yang Rui said again: "Everyone who came to the ion channel laboratory today is interested in the medicines that the laboratory is working on. Considering the professionalism of medicines, I have prepared some brochures for everyone. Look. Well, after reading it, please return the booklet."

With that said, someone started distributing paper products printed in black and white.

"Gaucher's disease?" Leander opened the pamphlet and saw this proper term.

"Yes, glucocerebroside disease. According to the classification of Europe and the United States, this is a rare disease. The current number of patients in the world is not very large, about hundreds of thousands." Yang Rui After a pause, he said, "Therefore, in order to balance expenses, the partner I need should be capable of applying for rare diseases, preferably a company with sales experience in rare diseases..."

Yang Rui spoke hundreds of words eloquently before letting the translator speak.

Representatives of several companies did not pay much attention to this aspect.

Large pharmaceutical companies have all hands and eyes, and they can handle even transnational politics, let alone the compliance application in their hometown.

The main point of their real concern is still whether Yang Rui can make a new drug.

"Which solution do you want to use to develop drugs for Gaucher's disease? What's the current progress?" The manager of GlaxoSmithKline put on his glasses and dragged them lightly, showing a shrewd look.

"Enzyme substitution method." Yang Rui replied without hesitation.

Gaucher disease is a disease caused by a genetic mutation. In the final analysis, it is the lack of glucocerebrosidase. Because the structure of glucocerebrosidase in the patient's body has changed, it can't perform its due function, which makes the human body produce a series of symptoms, such as splenomegaly, anemia, bone lesions and nervous system disorders.

Theoretically, supplementing a sufficient amount of glucosidase can improve the symptoms of patients with this disease.

However, this is obviously not an easy task, rb enzyme has no effect at this time.

The manager of GlaxoSmithKline looked at Yang Rui suspiciously, and asked, "The enzyme substitution method is said to be extremely expensive, and it is used for pharmaceutical-grade production. Can it be done?"

"It's good to reduce the cost. In this regard, I am still very confident."

Yang Rui's expression was also full of confidence.

The development of new drugs is no stranger to Yang Rui.

To put it bluntly, there are no more than 200 scientific research institutes all over the world with Yang Rui's level of proficiency.

The reason for this certainty is that there are not yet 200 real new drugs developed by people who are still alive in the world.

Don’t look at the 1990s. There were more than 4,000 types of new drugs developed in the entire Western world, or the whole world. However, a real new drug is to use a brand new compound instead of an isomer of an old compound. The total number of new drugs successfully completed is more than 100.

Deferiprone is one of them.

Although Yang Rui did not operate the whole process until deferiprone was launched, there is actually not much that developers can do for new drugs after the second phase of clinical trials. Unless they want to cheat, new drugs starting from the third phase are basically outsourced to Specialized companies are doing clinical trials. Thousands of clinical patients need clinicians, not drug developers. At this time, developers can no longer modify the composition of active substances. In fact, they can only resign themselves to fate.

After a fateful decision, deferiprone has already completed the development of a new drug so easily that it is facing the market, and there are not many repetitions. This result, to be honest, surprised some analysts.

Now, with the addition of the Nobel Prize, Yang Rui's success is taken for granted. The news that Peking University's ion channel laboratory is trial-producing new drugs has attracted so many pharmaceutical companies all at once.

However, it is one thing for a pharmaceutical company to be interested, and another for investment or cooperation. Leander looked at the manager of GSK again, hoping that he could ask Yang Rui further in order to get more information. Good judgment.

Sure enough, the manager of GlaxoSmithKline hesitated for a few seconds, then raised his head again, and said, "Our GlaxoSmithKline is willing to invest 1 million US dollars to obtain a 10% interest in the future of the drug. Is this okay?"

Liandel's jaw almost dropped when he heard that, so he gave money? Are you so rich?

Liandel quickly looked at the others, only to see the manager of Greenstone Corner, Shi Shiran, said: "1.5 million US dollars, 10% interest!"

Just one round of bidding raised the price of Yang Rui's unfinished new drug by US$5 million.

Leander was dumbfounded, aren't you afraid of being tricked by Yang Rui?

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