Rebirth of the God-level Xueba

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After Yao Yue started working, she was still a little uneasy.

But soon, she found that she didn't need to be nervous.

Because Yang Rui works so seriously that he has no time to care whether her dress and white coat really accompany her.

The workload of producing coenzyme Q10 by plant extraction is too great.

Especially since Yang Rui is ambitious and wants to establish a research and development chain, this task is even heavier.

In order to finally produce cheaper coenzyme Q10, the most important step is to extract the intermediate product solanesol from tobacco leaves, and then use solanesol as the intermediate product to chemically synthesize coenzyme Q10.

Extracting solanesol from tobacco leaves actually has related technologies.

Even using solanesol as a raw material to chemically synthesize coenzyme Q10, there were related papers and laboratory results in 1959.

However, a paper is a paper after all, and research is research after all. Just like the pure chemical synthesis of coenzyme Q10, since the 1960s, there have been related papers and researches, and more than one team has obtained coenzyme Q10 through chemical synthesis. However, until half a century later, the production of coenzyme Q10 by chemical synthesis still cannot be industrialized.

The semi-plant extraction and semi-chemical synthesis method also took about 30 years to mature. The key factor is to use 90% pure solanesol as the raw material.

If you realize this now, Yang Rui may be the only one in the world.

It can be said that just such a sentence can be exchanged for an industry worth billions of dollars in the future.

It's a pity that Yang Rui couldn't just say that.

If he uses an experiment or a paper to say it, he may be highly praised and affirmed by the biological community, but money is not a concern.

Japan, West Germany, the United States, France, the United Kingdom... There are too many super pharmaceutical companies that can use a strong research team and a pure gold lawyer team to throw Yang Rui out of the income zone.

To say that Big Pharma is the most despicable company in the world is somewhat arbitrary, but anyone who says they are not despicable must get booed.

Even the employees of pharmaceutical companies dare to say that our company does charity at most, but they dare not say that their company is charity.

Therefore, Yang Rui must build a series of key technologies around the core technology, and then use a series of technologies to surround a series of key technologies.

For example, the synthesis of 90% pure solanesol requires a series of key technical support.

The advantage of such layers of barriers is that Yang Rui does not need to apply for a patent for the core technology, or simply make a patented submarine, and only produce finished products for sale in a strictly confidential manner.

This is also a magic weapon for small and medium-sized biotechnology companies to survive.

In the early 1980s, many biotechnology companies did not understand this point, thinking that patents could protect themselves, but they were killed by large pharmaceutical companies one by one.

These days, the average lifespan of a biotech company in the United States is only 36 months. If legal fees are added, most medium-sized biotech companies with a capital of less than 50 million US dollars will not even be able to survive 18 months.

At the level of large pharmaceutical companies, let alone delays of 18 months, lawsuits that have been delayed for more than 8 years abound.

This is also one of the reasons why Yang Rui dare not make medicine for the time being.

Western medicine has a fixed name, usually a compound. Moreover, most of them are derivatives of compounds known in the medical field, except that the side chains of the branched chains are different, which is not surprising.

For this kind of medicine, it is very easy to be imitated. If it is to make money, it is almost a matter of course to be imitated.

Production technology is quite different. As long as the secrecy is done well, coupled with certain technological upgrades, it is no problem to maintain the monopoly interests for several years.

Biotechnology companies monopolize and earn money for several years, no matter how small the field is, it means a huge amount of money.

Japanese pharmaceutical companies have used half plant and half chemical synthesis for five or six years, and they have accumulated enough funds to complete the research and development of the microbial fermentation method, and at the same time, the dividends are very soft.

Yang Rui has developed the technology of plant extraction and semi-chemical synthesis now, and he can earn more money for several years.

Thinking of this, Yang Rui was also full of energy.

In just one weekend, several verification experiments were completed.

He didn't intend to stop. He continued to find several journals and continued to do verification experiments. At the same time, Yang Rui also started to write the first review.

In academia, a review can be seen as a high-level science popularization.

A review is a paper in which the author reorganizes the data, materials and opinions of a large number of papers on a certain topic, and then analyzes and refines the paper.

To put it simply, Yang Rui only needs to summarize the articles he read recently around a proposition, which is considered a summary.

For example, "Research Status of Solanesol" is an ordinary review article.

However, it is more difficult to publish this kind of article, and it is even more difficult to publish it in a better journal.

In European and American countries, especially the United States and the United Kingdom, the reviewers are often experts in the field, and they feel like giving lectures to ordinary researchers in simple terms.

Of course, their motivations for writing reviews are usually not so pure. Most of the time, Daniel writes a review to mix up the indicators of the paper. Because many foreign schools also have strict requirements on how many papers to write every year or every few years, some big cows are unable to complete the required number either out of laziness or excellence, so they just write a review and get away with it.

Because it is an advanced science popularization, there is no need for in-depth research. After checking some information, a summary can usually be written in a few days.

Domestic reviews are often written by gentlemen who are far away from Daniel. Some graduate students who can’t make a thesis or want to mix it up, some young lecturers who can’t complete the task, or busy associate professors are all big reviewers. The level is naturally uneven, so that some departments simply write Overviews are listed separately.

However, the Chinese academia in the 1980s was not so particular. Limited by the level, the review is still a very popular category, and people who rely on it to mix professional titles are like crossing the river.

Yang Rui didn't want to waste his research on so many materials, and the more papers he had with technical barriers, the better, so he unceremoniously began to write.

Lu Zhi, who was helping in the laboratory, saw how easy he was writing, and he wrote a large page in one afternoon, so he couldn't help asking: "Is this how you write a thesis?"

"This is the first paper, starting from a simple one." Yang Rui wrote the paper at a fast speed, because a lot of information is stored in his mind, and he has a clear understanding of the future development direction, so it is naturally easier to write the review.

Seeing that all his writing was in English, Lu Zhi naturally knew that it was going to be published abroad, so she couldn't help asking: "Can it really be published?"

Yang Rui said angrily: "I can't publish it, what should I write it for?"

"It's normal to write an article that can't be published. Many brothers and sisters are desperately trying to correct it, and some have to correct it for several years." Lu Zhi is still talking about the struggling type. If you are not struggling enough, you will never think of publishing an article abroad. .

Yang Rui smiled disapprovingly: "I'm different from them."

Now, even Yao Yue asked, "What's different?"

"Talent." Yang Rui pointed to his head, half-truthfully said: "I have a lot of things in my head."

"You mean to say that my mind is empty." Lu Zhi is not proficient in experiments, and she doesn't have many opportunities to get in touch with instruments, let alone Yang Rui's unfamiliar instruments. In the past two days, her performance has not been as good as middle school student He Cheng. How much is some emotional accumulation.

For a silly girl like Lu Zhi, when she has an idea, she pours it out immediately, and she can't keep it.

Yang Rui laughed twice, and silently acquiesced.

Angrily, Lu Zhi grabbed Yao Yue and said, "Let's go. If we don't do it to him, we're not only tired, but also scolded. You're like a capitalist. Whoever does it for you is a puppy."

Yao Yue was in a difficult situation, and Yang Rui said faintly: "The cafeteria cooks braised pork at noon, thanks to you."

Lu Zhi stopped unconsciously, and after a while, she called softly: "Wow!"

Yao Yue couldn't laugh or cry, so she said in shame: "Lu Zhi, you can't just..."

"Just what?"

"It's called..." Yao Yue stamped her feet before finishing her sentence.

Lu Zhi said indifferently: "What is this? When the educated youth orders, if the kitchen makes a pot of braised pork, everyone can line up to order it for a day. If the order is over, and there is no braised pork, everyone can rush up and kill the captain in the kitchen .”

The last sentence was obviously a threat to Yang Rui.

"Have you ever been an educated youth?" Yang Rui quickly changed the subject.

"There are a lot of educated youths in the school. I went home and repeated the exam for a year before I was admitted. Fortunately, I passed the exam. Otherwise, I would have to go to the coal mine. A former classmate of mine went to the coal mine to do ore processing for two years, and the tinnitus I can’t sleep at night, because my head is full of machine sounds.” Lu Zhi complained mixed with joy.

He Cheng, who has been doing experiments all the time, heard this, and suddenly said: "My second cousin sold the family's pigs last year in order to enter the coal mine, bought cigarettes and alcohol as gifts, and then arranged temporary workers for him. He will go down the mine for two years. , only then became a regular. Their family eats vegetarian dumplings during the Spring Festival."

Going to the coal mine is not as good as studying, but being a farmer is not as good as going to the coal mine. This answer immediately silenced the two college girls.

Yang Rui didn't like this kind of atmosphere, so he coughed and said, "Yao Yue, you also write a review and show it to me next week."

"Me? I still can't understand some words..." Yao Yue was slightly nervous. Now there is no search engine that can help translate English. Unknown words have to be looked up one by one. Uncommon professional English can only be looked up by professional dictionaries, and the workload is huge.

Yang Rui shook his head: "It's not for you to write in English. Write an article in Chinese first. It's not a waste anyway. It can be regarded as accumulating some experience. I'll help you revise the thesis after I finish writing it, and then I will teach you how to write a cover letter. Signature is also counted." your own."

Just like a big cow in later generations, Yang Rui didn't even bother to leave his name in ordinary domestic journals, let alone this kind of review of small articles like practicing pens.

Yao Yue relaxed for a while, then became nervous again, and whispered: "Can I write it?"

"How will you know if you don't try it. Okay, you guys go and pack your bags and go back after lunch. Yao Yue, if you have any questions, mail... to me, write a letter, um, I have an experiment for you to do, and I will also Write to you to explain the requirements and steps of the experiment, and mail back the details when you have the results. Remember to memorize the English words, and start reading English literature next month.” In addition to being mailed, Yang Rui’s request is the same as when he was in his second year of research , the instructor's requirements are similar.

There are very few graduate students these days. Excellent undergraduates would have to undertake the task of assisting in experiments. Yang Rui now has a good understanding of Yao Yue's experimental ability. As long as she does not assign tasks that exceed her ability, there will be no mistakes.

Lu Zhi read the braised pork silently, and briskly went to the locker room. Yao Yue left a little hesitantly, with nostalgia for the laboratory and people, and anticipation for writing his own paper.

"If the students in the class know that I have the opportunity to independently write a paper and publish it, they must be envious." Yao Yue's vanity also slightly fermented. She is only a sophomore girl this year. If she has the opportunity to publish a paper, she might be the man of the year at Hedong University.

...